Viral Replication

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What are the basic stages of viral replication?
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The basic stages are attachment, penetration, uncoating, replication, assembly, and release.
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What is the role of the host cell in viral replication?
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The host cell provides the machinery and environment for the virus to replicate its genome and synthesize viral proteins.
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How do DNA and RNA viruses differ in their replication method?
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DNA viruses typically use the host's DNA polymerase for replication, while RNA viruses often carry their own RNA-dependent RNA polymerase.
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What is reverse transcription, and which viruses use it?
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Reverse transcription is the process of converting RNA into DNA, used by retroviruses like HIV.
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Why do viruses need to uncoat during replication?
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Uncoating releases the viral genome inside the host cell and is essential for subsequent replication steps.
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How does the assembly of new viruses occur?
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Viral components self-assemble into new virions in the host cell's cytoplasm or nucleus.
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What is lysis in the context of viral replication?
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Lysis is the breaking down of a host cell to release newly formed viruses.
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What distinguishes lytic from lysogenic viral cycles?
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The lytic cycle results in immediate cell lysis, while the lysogenic cycle involves viral DNA integrating into the host genome without immediate destruction.
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Why are some viruses host-specific?
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Host specificity is determined by the compatibility between viral surface proteins and host cell receptors.
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How do antiviral drugs target stages of viral replication?
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Antiviral drugs can inhibit viral entry, uncoating, replication enzymes, assembly, or release.
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What is the significance of the eclipse phase in viral replication?
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The eclipse phase is when viruses cannot be detected in the host as they are disassembled within the host cell, prior to new virion assembly.
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How do bacteriophages replicate within bacterial hosts?
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Bacteriophages inject their DNA into bacteria, use bacterial machinery for replication, and often cause bacterial lysis to release new virions.
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What role does genetic variation play in viral replication?
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High mutation rates in viral replication lead to genetic diversity, impacting immune evasion and drug resistance.
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Why do RNA viruses generally have a higher mutation rate than DNA viruses?
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RNA viruses have higher mutation rates due to their lack of proofreading mechanisms during replication.
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How does viral packaging occur during replication?
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During viral packaging, newly synthesized viral genomes and proteins are enclosed within a protein coat to form virions.
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