Epigenetics is the study of changes in gene expression that do not involve changes to the underlying DNA sequence.
How do epigenetic changes contribute to cancer development?
Epigenetic changes can turn off tumor suppressor genes or activate oncogenes, which can lead to uncontrolled cell growth and cancer development.
What are the different types of epigenetic modifications?
The different types of epigenetic modifications include DNA methylation, histone modification, and non-coding RNA regulation.
How does DNA methylation contribute to cancer development?
DNA methylation can silence tumor suppressor genes, which can lead to cancer development.
What is histone modification?
Histone modification refers to changes to the proteins around which DNA is wrapped, which can affect gene expression.
What is the role of non-coding RNA in epigenetics and cancer?
Non-coding RNA can regulate gene expression through epigenetic mechanisms, and dysregulation of non-coding RNA has been implicated in cancer development.
What is epigenetic therapy?
Epigenetic therapy refers to treatments that target epigenetic modifications to restore normal gene expression and potentially treat cancer.
What is DNA demethylation?
DNA demethylation is the process of removing methyl groups from DNA, which can reactivate tumor suppressor genes that have been silenced by DNA methylation.
How does chromatin remodeling impact epigenetics and cancer?
Chromatin remodeling can affect gene expression and contribute to cancer development if tumor suppressor genes are silenced or oncogenes are activated.
What is the relationship between epigenetics and cancer metastasis?
Epigenetic changes can promote cancer cell invasion and metastasis, which can make the cancer more difficult to treat.
What is the epigenetic clock?
The epigenetic clock is a measure of biological age based on patterns of DNA methylation that change over time and can predict cancer risk.
What are the challenges in targeting epigenetic modifications for cancer therapy?
One challenge is specificity, as epigenetic targets may be involved in multiple cellular processes. Another challenge is toxicity, as some epigenetic targets are critical for normal cellular function.
How can epigenetics research lead to cancer prevention and early detection?
Epigenetic changes can occur early in cancer development and may be detectable in bodily fluids, making them potential biomarkers for cancer prevention and early detection.
What is the role of epigenetics in cancer immunotherapy?
Epigenetic changes can affect the expression of immune-related genes and impact the response to cancer immunotherapy.
How are epigenetic modifications involved in resistance to cancer therapy?
Epigenetic modifications can lead to resistance to chemotherapy and other cancer treatments by affecting gene expression and cellular pathways involved in drug response.
What is epigenetics?
Epigenetics is the study of changes in gene expression that do not involve changes to the underlying DNA sequence.
How do epigenetic changes contribute to cancer development?
Epigenetic changes can turn off tumor suppressor genes or activate oncogenes, which can lead to uncontrolled cell growth and cancer development.
What are the different types of epigenetic modifications?
The different types of epigenetic modifications include DNA methylation, histone modification, and non-coding RNA regulation.
How does DNA methylation contribute to cancer development?
DNA methylation can silence tumor suppressor genes, which can lead to cancer development.
What is histone modification?
Histone modification refers to changes to the proteins around which DNA is wrapped, which can affect gene expression.
What is the role of non-coding RNA in epigenetics and cancer?
Non-coding RNA can regulate gene expression through epigenetic mechanisms, and dysregulation of non-coding RNA has been implicated in cancer development.
What is epigenetic therapy?
Epigenetic therapy refers to treatments that target epigenetic modifications to restore normal gene expression and potentially treat cancer.
What is DNA demethylation?
DNA demethylation is the process of removing methyl groups from DNA, which can reactivate tumor suppressor genes that have been silenced by DNA methylation.
How does chromatin remodeling impact epigenetics and cancer?
Chromatin remodeling can affect gene expression and contribute to cancer development if tumor suppressor genes are silenced or oncogenes are activated.
What is the relationship between epigenetics and cancer metastasis?
Epigenetic changes can promote cancer cell invasion and metastasis, which can make the cancer more difficult to treat.
What is the epigenetic clock?
The epigenetic clock is a measure of biological age based on patterns of DNA methylation that change over time and can predict cancer risk.
What are the challenges in targeting epigenetic modifications for cancer therapy?
One challenge is specificity, as epigenetic targets may be involved in multiple cellular processes. Another challenge is toxicity, as some epigenetic targets are critical for normal cellular function.
How can epigenetics research lead to cancer prevention and early detection?
Epigenetic changes can occur early in cancer development and may be detectable in bodily fluids, making them potential biomarkers for cancer prevention and early detection.
What is the role of epigenetics in cancer immunotherapy?
Epigenetic changes can affect the expression of immune-related genes and impact the response to cancer immunotherapy.
How are epigenetic modifications involved in resistance to cancer therapy?
Epigenetic modifications can lead to resistance to chemotherapy and other cancer treatments by affecting gene expression and cellular pathways involved in drug response.